Genetics & Biomedical · Paper · 2015

Commentary: Portuguese crypto-Jews: the genetic heritage of a complex history

Alexander W. Marcus, Emily R. Ebel, Daniel A. Friedman

Frontiers in Genetics

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Overview

This commentary critiques Nogueiro et al. (2015), who used Y chromosome and mitochondrial DNA haplotype data from contemporary Iberian and non-Iberian populations to explore a diagnostic genetic signature of Portuguese "crypto-Jews." The authors identify two main weaknesses: (1) the matrilineal and patrilineal markers reviewed are methodologically inadequate as "reliable Jewish ancestry predictors" due to haplotype polyphyly and molecular clock ambiguity — many ostensibly "Jewish" haplotypes are

Jewish geneticshaplotypescrypto-JewsIberian Peninsulaadmixturedemographic historyY-chromosomemtDNApopulation genetics

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Methods and contributions

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Findings and contributions

  • The authors argue the reviewed data are ambiguous for inferring Jewish ancestry and do not identify diagnostic patrilineal or matrilineal markers.
  • Many 'Jewish' haplotypes cited are pan-Middle Eastern markers also common in Arabic lineages, so their ancestry is ambiguous.
  • The commentary contends the 'complex mating strategies' hypothesis was not tested against demographic or admixture models, and small uniparental samples cannot support robust conclusions.
  • The authors propose that admixture in the Bragança Jews and a bottleneck in the Belmonte Jews could be statistically evaluated with existing demographic models.
  • They conclude the results offer no concrete support for specific claims about the mating habits, beliefs, or praxis of these historical Jewish populations.

Methods

  • Critical commentary on Nogueiro et al. (2015) uniparental-marker study — Evaluates the Y-chromosome and mtDNA evidence and inferences of Nogueiro et al. on Portuguese crypto-Jews via two stated critiques.
  • Comparison against prior work on Jewish haplotype motifs — Uses Tofanelli et al. (2014) and related studies to assess whether the cited haplotypes are diagnostic of Jewish ancestry.

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Citation

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Marcus, Alexander W.; Ebel, Emily R.; Friedman, Daniel A. 2015. Commentary: Portuguese crypto-Jews: the genetic heritage of a complex history. Frontiers in Genetics. DOI: 10.3389/fgene.2015.00261. URL: https://doi.org/10.3389/fgene.2015.00261.
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Catalog row106
Citation keyFriedman2015CommentaryPortugueseCryptoJews106
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