Influence of Nuclear Structure on formation of radiation-induced lethal lesions

Catalog Row105

Citation KeyFriedman2016InfluenceNuclearStructureFormation105

Paper FolderAvailable

DOI10.3109/09553002.2016.1144941

Overview

Extracted from the local paper documentation when available.

This paper discusses the influence of nuclear structure on the formation of radiation-induced lethal lesions, particularly focusing on the rejoining of fragmented nuclear DNA caused by ionizing radiation. It synthesizes existing knowledge with new insights from high-throughput sequencing data to better understand how spatial organization within the genome affects the generation of lethal chromosome aberrations.

Hi-Cchromosome conformationradiation biologychromatin architectureDNA damagetopologically associating domainsnuclear organization3C technologies

Use Notes

Concise findings and methods pulled from README/SKILL documentation.

Findings / Concepts

Synthesis of existing knowledge with new insights from high-throughput sequencing data.
Identification of the fractal globule organization of DNA and its implications for radiation damage.
Exploration of the spatial proximity of transcriptionally active euchromatin and its susceptibility to radiation.
Discussion of the temporal factors influencing the formation of lethal lesions post-irradiation.

Methods / Techniques

High-throughput sequencing of chromosome conformation capture experiments.
Analysis of spatial organization of DNA within the nucleus.
Examination of transcriptional programs linking genomic locations.
Review of existing models of radiation-induced DNA damage and repair mechanisms.

Citation

Plain-text citation for quick reuse.

Friedman, Daniel Ari. 2016. Influence of Nuclear Structure on formation of radiation-induced lethal lesions. Int. J. Radiation Biology.

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