Large Scale Coding Sequence Change Underlies the Evolution of Post-developmental Novelty in Honey Bees

This study investigates the role of coding sequence changes in the evolution of postdevelopmental novelty in honey bees, challenging the traditional evo-devo paradigm that emphasizes regulatory changes. Through RNA-Seq experiments, we demonstrate that positively selected, tissue-specific genes with low network connectivity are crucial for the emergence of novel physiological functions in adult honey bees.