{
  "title": "NuclearStructure",
  "domain": "Genetics & Biomedical",
  "type": "Paper",
  "creators": [
    {
      "name": "Daniel A. Friedman"
    },
    {
      "name": "Daniel F. Pilch"
    }
  ],
  "description": "Ionizing radiation causes DNA double-strand breaks and disrupts chromatin architecture, potentially leading to chromosomal aberrations and genomic instability. Chromosome conformation capture (3C) tec...",
  "abstract": "Ionizing radiation causes DNA double-strand breaks and disrupts chromatin architecture, potentially leading to chromosomal aberrations and genomic instability. Chromosome conformation capture (3C) technologies, particularly Hi-C, have revolutionized our understanding of three-dimensional genome organization. Here we review the intersection of radiation biology with chromatin conformation studies, examining how radiation impacts nuclear organization at multiple scales from nucleosomes to chromoso",
  "keywords": [
    "Hi-C",
    "chromosome conformation",
    "radiation biology",
    "chromatin architecture",
    "DNA damage",
    "topologically associating domains",
    "nuclear organization",
    "3C technologies"
  ],
  "methods": [
    {
      "name": "Genomic and bioinformatic analysis",
      "description": "Applied genomic and bioinformatic analysis approach"
    },
    {
      "name": "Statistical genetics",
      "description": "Applied statistical genetics approach"
    }
  ],
  "key_findings": [
    "Ionizing radiation causes DNA double-strand breaks and disrupts chromatin architecture, potentially leading to chromosomal aberrations and genomic instability..",
    "Chromosome conformation capture (3C) tec...."
  ],
  "related_papers": [
    "2015_CryptoJews",
    "2015_EhrlichialInfection",
    "2015_HoneyBeeEvolution"
  ],
  "checked_at": "2026-07-01T20:50:01Z"
}